News

New publication: The evolutionary history of the DMRT3 'Gait keeper' haplotype.

Uppsala based researchers have genetically examined 382 horses representing 72 breeds and provide conclusive evidence that stop mutation in DMRT3 is causal. They show that the mutation probably arose within the last 10 000 years. Thus, the mutation occurred either just before domestication or more likely some time after domestication and then spread across the world as a result of selection on locomotion traits. This research article was published in Animal Genetics.

The evolutionary history of the DMRT3 'Gait keeper' haplotype.

 

New publication: Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters

A total of 769 Coldblooded trotters born in Sweden and Norway were included in the study. There was a significant difference in the frequency of the AA genotype between raced and unraced horses and less than 50% of the AA horses raced compared to 68% and 63% of CA and CC horses respectively. At the age of 3-6 yrs, the CA horses performed significantly better than the CC horses for almost all traits whilst there were no significant differences between CA and AA horses. The study, led by researchers at The Swedish university of Agricultural sciences, was published in “PLoS One”

Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters.

 

Capilet Genetics launches new DNA test.

Capilet Genetics launches a diagnostic DNA test for the developmental disorder "Skeletal atavism". The test is a precise tool for breeders that can prevent affected foals from being born.  

Click here to read more about the Skeletal Atavism TestTM

Link to press release

 

New publication: Large Deletions at the SHOX Locus in the Pseudoautosomal Region are associated with Skeletal Atavism in Shetland ponies.

Shetland Ponies are occasionally born with malformed legs, a genetic defect called Skeletal atavism. Researchers at the Swedish University of Agricultural Sciences and Uppsala University, together with three international research teams have now unravelled the genetics behind the disease, and the work was recently published in a scientific journal.

Large Deletions at the SHOX Locus in the Pseudoautosomal Region are associated with Skeletal Atavism in Shetland ponies

 

New publication: The DMRT3 ´Gait keeper´ mutation affects performance of Nordic and Standardbred trotters

Researchers showed that the DMRT3 mutation clearly influence trotting technique in coldblooded trotters. A group of standardbred paternal half-sibs was also studied and the result showed that AA offspring had significant better success on the racetrack compared to CA offspring. The study, led by researchers at The Swedish university of Agricultural sciences and Uppsala University, was recently published in the scientific journal Animal Genetics.

The DMRT3 ´Gait keeper´ mutation affects performance of Nordic and Standardbred trotters

 

New publication: The effect of the 'Gait keeper' mutation in the DMRT3 gene on gaiting ability in Icelandic horses.

Thorvaldur Kristjansson, Agricultural University of Iceland, has studied how the gene DMRT3 influence the gaits of the Icelandic horse. In addition to pace, the AA horses also have a higher average score for tölt. CA horses have higher average score for the basic gaits: walk, trot and canter. This research article was published in the Journal of Animal Breeding and Genetics.

The effect of the 'Gait keeper' mutation in the DMRT3 gene on gaiting ability in Icelandic horses.

 

Worldwide frequency distribution of the ‘Gait keeper’ mutation in the DMRT3 gene

New scientific publication describes the frequency of the DMRT3 gene variants in horses world-wide. The study, led by researcher at Uppsala University and The Swedish university of Agricultural sciences, was recently published in the scientific journal Animal Genetics.

Worldwide frequency distribution of the ‘Gait keeper’ mutation in the DMRT3 gene

 

SynchroGait is now available in more laboratories

Clink here to see where you can order the test SynchroGait.

High interest for our research in the media

We are bouyed by the high level of media attention our research has drawn from the global audience. A link to a subset of these articles is listed below.

SciLogs - Is “Horse Sense” Overrated? Nonsense Mutation Allows Novel Gaits 

The New York Times - Horses’ Ability to Pace Is Written in DNA

ABC Science - Gene mutation makes horses hot to trot

Ars technica - Single mutation keeps racehorses in the money

RedOrbit - Single Gene Has Impact On Gait Of Horses And Mice

Equus - Research Revelation: A Simple Gene Mutation Sets Gaited Horses Apart

Smartplanet - Mutation endows horses with wider gait repertoire

Science Illustrated - A single gene controls movement in vertebrates

Science omega - Pacing horses owe ability to gene mutation

 

The scientific result now published in Nature

Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice

framsida Nature

 

2012-08-29. The research result upon which the SynchroGait test is based is now published in the scientific journal Nature. Link to article. The study was also discussed in Nature News: Horse gait traced to single mutation.